The 25-year-old, who made the 30-man Ballon d’Or nomination list on Monday, was assessed by the club’s medical team upon his return from Senegal duty, where he featured for 87 minutes in the 2-0 World Cup qualifying win over Cape Verde.
The speedster sustained the problem in that encounter, with scans showing the damage is substantial enough to keep him out of action for over a month.
Saturday’s Premier League clash at Anfield against Jose Mourinho’s side is one of nine encounters Mane is set to miss, which also includes a trip to Tottenham and a test with Chelsea at home.
Both Champions League games against Maribor as well as the visit of Sevilla take place in the period of his expected absence too, along with the Anfield matches against Huddersfield and Southampton plus West Ham away.
Mane’s unavailability is a gigantic setback for Jurgen Klopp, who already been without Adam Lallana and Nathaniel Clyne since prior to the campaign kicking off through a thigh and back injury respectively.
The winger had only returned to domestic action in the 1-1 draw at Newcastle prior to the FIFA break having served a three-match ban following his sending off against Manchester City in September.
Mane has scored three goals in four top-flight appearances this term and is Liverpool's reigning Player of the Season. The club struggled to deal with his departure for the African Nations Cup in January and had to alter their style when he picked up meniscus damage in his left knee three months later.
Klopp has added Mohamed Salah, Dominic Solanke and Alex Oxlade-Chamberlain to his attacking options since then and will hope Liverpool can better handle the loss of one of their game-changers this time around.
WHICH GAMES COULD SADIO MANE MISS?
As a result of his setback, Mane is set to miss at least eight games, and faces a race against time to be fit for the home encounter with champions Chelsea on November 25, just four days after a Champions League clash with Sevilla.
| DATE | FIXTURE | COMPETITION | VENUE |
|---|---|---|---|
| Oct-14 | MANCHESTER UNITED | PREMIER LEAGUE | ANFIELD |
| Oct-17 | MARIBOR | CHAMPIONS LEAGUE | STADION LJUDSKI |
| Oct-22 | TOTTENHAM | PREMIER LEAGUE | WEMBLEY |
| Oct-28 | HUDDERSFIELD | PREMIER LEAGUE | ANFIELD |
| Nov-01 | MARIBOR | CHAMPIONS LEAGUE | ANFIELD |
| Nov-04 | WEST HAM | PREMIER LEAGUE | LONDON STADIUM |
| Nov-18 | SOUTHAMPTON | PREMIER LEAGUE | ANFIELD |
| Nov-21 | SEVILLA | CHAMPIONS LEAGUE | RAMON SANCHEZ PIZJUAN |
